Selected publications
 

Ewa Skrzypczak-Jankun , PhD
Associate Professor
Urology Research Center
Department of Urology
Mail Stop 1091
Health Science Campus
The University of Toledo
3000 Arlington
Toledo, OH 43614-2598
phone (419) 383-5414; FAX (419) 383-3785

 

  • Ansari M Aleem, Jerzy Jankun, John D Dignam, Matthias Walther, Hartmut Kuhn, Dmitri Svergun, Ewa Skrzypczak-Jankun,Human Platelet 12-Lipoxygenase, New Findings about Its Activity, Membrane Binding and Low Resolution Structure, Journal of Molecular Biology, 376(1), 193-209, 2008, accepted manuscript.
  • Jankun, J. Aleem, A. M. Selman, S. H. Skrzypczak-Jankun, E. Lysiak-Szydlowska, W. Grafos, N. Fryer, H. J. Greenfield, R. S. Highly stable plasminogen activator inhibitor type one (VLHL PAI-1) protects fibrin clots from tissue plasminogen activator-mediated fibrinolysis. International Journal of Molecular Medicine, 20,(5): 683-687, 2007, full paper in pdf.
  • Skrzypczak-Jankun, E., Chorostowska-Wynimko, J., Selman, S.H., Jankun J. Lipoxygenases – a challenging problem in enzyme inhibition and drug development. Current Enzyme Inhibition, 3(2), 119-132, 2007, invited paper, full paper in pdf.
  • Jankun, J. Aleem, A. M. Specht, Z., Keck, R. W. Lysiak-Szydlowska, W. Selman, S. H. Skrzypczak-Jankun, E. PAI-1 induces cell detachment, downregulates nucleophosmin (B23) and fortilin (TCTP) in LnCAP prostate cancer cells. International Journal of Molecular Medicine, 20,(1): 11-20, 2007, full paper in pdf.
  • Skrzypczak-Jankun, E. Borbulevych, O. Y. Zavodszky, M. I. Baranski, M. R. Padmanabhan, K. Petricek, V. Jankun, J. Effect of crystal freezing and small-molecule binding on internal cavity size in a large protein: X-ray and docking studies of lipoxygenase at ambient and low temperature at 2.0 A resolution. Acta Crystallographica D, Biological Crystallography, 62, Pt7, 766-775, 2006, full paper in pdf.
  • Jankun, J. Aleem, A. M. Malgorzewicz, S. Szkudlarek, M. Zavodszky, M. I. Dewitt, D. L. Feig, M. Selman, S. H. Skrzypczak-Jankun, E. Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells. Molecular Cancer Therapeutics, 5,(5), 1371-1382, 2006, full paper in pdf, journal cover
  • Jankun, J. Selman, S. H. Aniola J. Skrzypczak-Jankun, Nutraceutical inhibitors of urokinase: potential applications in prostate cancer prevention and treatment. Oncology Reports, 16(2), 341-346., 2006, full paper in pdf.
  • Jankun, J, Specht, Z., Szkudlarek, M., Greenfield, R., Gaikwad, B., Trifonov, L., Vaugeois, J., Aleem, M. A., Basrur, V., Selman, H. S., Zavodszky, I. M., Skrzypczak-Jankun, E. Plasminogen activator inhibitor-1 is locked in active conformation and polymerizes upon binding ligands neutralizing its activity, International Journal of Molecular Medicine, 17(3): 437-449, 2006, full paper in pdf, journal cover.
  • E. Skrzypczak-Jankun, O. Borbulevych, A. Melillo, R. Keck, M. Soriano-Garcia, J. Aniola, L. Lilge, M. Niedre, S. H. Selman, J. Jankun. Aspirin Blocks Binding of Photosensitizer SnET2 into Human Serum Albumin; Implications for Photodynamic Therapy. International Journal of Molecular Medicine, 15 (5): 777-783, 2005, full paper in pdf, journal cover.
  • Skrzypczak-Jankun, E., Borbulevych, O. Y., Jankun, J. Soybean lipoxygenase-3 in complex with 4-nitrocatechol. Acta Crystallogr D Biol Crystallogr, 60:Pt3, 613-615, 2004, full text in pdf.
  • Borbulevych, O. Y., Jankun, J., Selman, S. H., Skrzypczak-Jankun, E. Lipoxygenase interactions with natural flavonoid, quercetin, reveal a complex with protocatechuic acid in its X-ray structure at 2.1 A resolution, Proteins, 54:1, 13-19, 2004, full paper in pdf.
  • Chorostowska-Wynimko, J., Skrzypczak-Jankun, E., Jankun, J. Plasminogen activator inhibitor type-1: its structure, biological activity and role in tumorigenesis (Review), International Journal of Molecular Medicine, 13:6, 759-766, 2004, full paper in pdf.
  • Chorostowska-Wynimko, J., Swiercz, R., Skrzypczak-Jankun, E., Wojtowicz, A., Selman, S. H., Jankun, J. A novel form of the plasminogen activator inhibitor created by cysteine mutations extends its half-life: relevance to cancer and angiogenesis, Molecular Cancer Therapeutics, 2:1, 19-28, 2003, full paper in pdf, journal cover.
  • Skrzypczak-Jankun, E., Zhou, K., Jankun, J. Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead. International Journal of Molecular Medicine, 12:4, 415-420, 2003, full paper in pdf.
  • Zeng H, Zhu J, Yuan L, Han Y, Cheng S, Furukawa M, Parra RD, Kovalevsky AY, Mills JL, Skrzypczak-Jankun E, Martinovic S, Smith RD, Zheng C, Szyperski T, .Zeng XC. Creating nanocavities of tunable sizes: hollow helices, Proc Natl Acad Sci U S A, 99(18), 11583-11588, 2002, full paper in pdf.
  • Skrzypczak-Jankun E, Bross RA, Carroll RT, Dunham WR, Funk MO, Jr. Three-dimensional structure of a purple lipoxygenase, J Am Chem Soc, 123(44), 10814-10820, 2001, full text in pdf.
  • Jankun, J, Skrzypczak-Jankun, E. Binding site of amiloride to urokinase plasminogen activator depends on species. International Journal of Molecular Medicine, accepted, 2001, full paper in pdf.
  • Swiercz, R., Keck, R. W., Skrzypczak-Jankun, E., S, Selman, H. S., and Jankun, J. Recombinant PAI-1 inhibits angiogenesis and reduces size of LNCaP prostate cancer xenografts in SCID mice, Oncology Reports, 8: 463-470, 2001, full paper in pdf.
  • Jankun, J., Skrzypczak-Jankun, E. Binding site of amiloride to urokinase plasminogen activator depends on species, International Journal of Molecular Medicine, 8:4, 365-371, 2001, full paper in pdf.
  • Skrzypczak-Jankun, E., McCabe, P. N., Selman, S. H., and Jankun, J. Curcumin Inhibits Lipoxygenase by Binding to its Central Cavity: Theoretical and X-ray Evidence. International Journal of Molecular Medicine, 6: 521-526, 2000, full paper in pdf.
  • Swiercz R, Skrzypczak-Jankun E, Merrell M M, Selman H S, Jankun J. Angiostatic Activity of Synthetic Inhibitors of Urokinase Type Plasminogen Activator, Oncology Reports, 6: 523-536, 1999 full paper in pdf.
  • Jankun J, Skrzypczak-Jankun, E. Molecular Basis of Specific Inhibition of Urokinase Plasminogen Activator by Amiloride, Cancer Biochemistry Biophysics, 17:109-123, 1999, full paper in pdf
  • Chau Pham, Jankun, J. Skrzypczak-Jankun, E. Flowers II, R.A.and Funk, M. O. Jr. Structural and Thermochemical Characterization of Lipoxygenase Catechol Complexes. Biochemistry, 37(51): 17952-17957, 1998, full text in pdf.
  • Skrzypczak-Jankun E, Amzel LM, Kroa BA, Funk MO, Jr. Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme, Proteins, 29(1), 15-31, 1997, full text in pdf, full paper in pdf, journal cover.
  • Jankun J. Keck RW, Skrzypczak-Jankun E, Swiercz, R. Inhibitors of urokinase reduce size of prostate cancer xenografts in severe combined immunodeficient mice, Cancer Research, 57(4), 559-563, 1997, full text in pdf..
  • Jankun J, Selman SH, Swiercz R, Skrzypczak-Jankun E. Why drinking green tea could prevent cancer, Nature, 387, 6633, 562, 1997, full paper in pdf.
  • Skrzypczak-Jankun E, Bianchet MA, Mario Amzel L, Funk MO, Jr.Flash-freezing causes a stress-induced modulation in a crystal structure of soybean lipoxygenase l3, Acta Crystallogr D Biol Crystallogr, 52, 959-965, 1996, full paper in pdf.
  • Ramachandran S, Richards-Sucheck TJ, Skrzypczak-Jankun E, Wheelock MJ, Funk MO, Jr. Catalysis sensitive conformational changes in soybean lipoxygenase revealed by limited proteolysis and monoclonal antibody experiments, Biochemistry, 34(45), 14868-14873, 1995, full paper in pdf.
  • Seshadri TP, Skrzypczak-Jankun E, Yin M, Tulinsky A. Differences in the metal ion structure between Sr- and Ca-prothrombin fragment 1, Biochemistry, 33(5), 1087-1092, 1994, full paper in pdf.
  • Skrzypczak-Jankun E, Carperos VE, Ravichandran KG, Tulinsky A, Westbrook M, Maraganore JM. Structure of the hirugen and hirulog 1 complexes of alpha-thrombin, J Mol Biol, 221(4), 1379-1393, 1991.
  • Seshadri TP, Tulinsky A, Skrzypczak-Jankun E, Park CH. Structure of bovine prothrombin fragment 1 refined at 2.25 A resolution, J Mol Biol, 220(2), 481-494, 1991.
  • Soriano-Garcia M, Park CH, Tulinsky A, Ravichandran KG, Skrzypczak-Jankun E. Structure of Ca2+ prothrombin fragment 1 including the conformation of the Gla domain, Biochemistry, 28(17), 6805-6810, 1989