Selected publications
 

Jerzy Jankun, PhD
Professor
Director Urology Research Center
Department of Urology
Mail Stop 1091
Health Science Campus
The University of Toledo
3000 Arlington
Toledo, OH 43614-2598
phone (419) 383-3691; FAX (419) 383-3785

 

  • Ansari M Aleem, Jerzy Jankun, John D Dignam, Matthias Walther, Hartmut Kuhn, Dmitri Svergun, Ewa Skrzypczak-Jankun, Human Platelet 12-Lipoxygenase, New Findings about Its Activity, Membrane Binding and Low Resolution Structure, Journal of Molecular Biology, 376(1), 193-209, 2008, accepted manuscript.
  • Jankun, J. Aleem, A. M. Selman, S. H. Skrzypczak-Jankun, E. Lysiak-Szydlowska, W. Grafos, N. Fryer, H. J. Greenfield, R. S. Highly stable plasminogen activator inhibitor type one (VLHL PAI-1) protects fibrin clots from tissue plasminogen activator-mediated fibrinolysis. International Journal of Molecular Medicine, 20,(5): 683-687, 2007, full text in pdf.
  • Skrzypczak-Jankun, E., Chorostowska-Wynimko, J., Selman, S.H., Jankun J. Lipoxygenases – a challenging problem in enzyme inhibition and drug development. Current Enzyme Inhibition, 3(2), 119-132, 2007, invited paper, full text in pdf.
  • Jankun, J. Aleem, A. M. Specht, Z., Keck, R. W. Lysiak-Szydlowska, W. Selman, S. H. Skrzypczak-Jankun, E. PAI-1 induces cell detachment, downregulates nucleophosmin (B23) and fortilin (TCTP) in LnCAP prostate cancer cells. International Journal of Molecular Medicine, 20,(1): 11-20, 2007, full text in pdf.
  • Skrzypczak-Jankun, E. Borbulevych, O. Y. Zavodszky, M. I. Baranski, M. R. Padmanabhan, K. Petricek, V. Jankun, J. Effect of crystal freezing and small-molecule binding on internal cavity size in a large protein: X-ray and docking studies of lipoxygenase at ambient and low temperature at 2.0 A resolution. Acta Crystallographica D, Biological Crystallography, 62, Pt7, 766-775, 2006, full paper in pdf.
  • Jankun, J. Aleem, A. M. Malgorzewicz, S. Szkudlarek, M. Zavodszky, M. I. Dewitt, D. L. Feig, M. Selman, S. H. Skrzypczak-Jankun, E. Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells. Molecular Cancer Therapeutics, 5,(5), 1371-1382, 2006, full paper in pdf, journal cover
  • Jankun, J. Selman, S. H. Aniola J. Skrzypczak-Jankun, Nutraceutical inhibitors of urokinase: potential applications in prostate cancer prevention and treatment. Oncology Reports, 16(2), 341-346., 2006, full paper in pdf.
  • McCabe, N. P. Selman, S. H. Jankun, J. Vascular endothelial growth factor production in human prostate cancer cells is stimulated by overexpression of platelet 12-lipoxygenase. Prostate, 66(7): 779-787, 2006, full paper in pdf.
  • Jankun, J, Specht, Z., Szkudlarek, M., Greenfield, R., Gaikwad, B., Trifonov, L., Vaugeois, J., Aleem, M. A., Basrur, V., Selman, H. S., Zavodszky, I. M., Skrzypczak-Jankun, E. Plasminogen activator inhibitor-1 is locked in active conformation and polymerizes upon binding ligands neutralizing its activity, International Journal of Molecular Medicine, 17(3): 437-449, 2006, full paper in pdf, journal cover.
  • E. Skrzypczak-Jankun, O. Borbulevych, A. Melillo, R. Keck, M. Soriano-Garcia, J. Aniola, L. Lilge, M. Niedre, S. H. Selman, J. Jankun. Aspirin Blocks Binding of Photosensitizer SnET2 into Human Serum Albumin; Implications for Photodynamic Therapy. International Journal of Molecular Medicine, 15 (5): 777-783, 2005, full paper in pdf, journal cover.
  • Miocinovic, R., McCabe, N. P., Keck, R. W., Jankun, J., Hampton, J. A., and Selman, S. H. In vivo and in vitro effect of baicalein on human prostate cancer cells. Int J Oncol, 26: 241-246, 2005, full text in pdf.
  • Jankun, J., Lilge, L., Douplik, A., Keck, R. W., Pestka, M., Szkudlarek, M., Stevens, P. J., Lee, R. J., Selman, S. H. Optical characteristics of the canine prostate at 665 nm sensitized with tin etiopurpurin dichloride: need for real-time monitoring of photodynamic therapy. The Journal of Urology, 172(2), 739-743, 2004, full paper in pdf, journal cover
  • Lothar Lilge, Natalie Pomerleau-Dalcourt, Alexander Douplik, Steven H Selman, RickW Keck, Maria Szkudlarek, Maciej Pestka and Jerzy Jankun. Transperineal in vivo fluence-rate dosimetry in the canine prostate during SnET2-mediated PDT, Physics in Medicine and Biology, 49, 3209–3225, 2004, full paper in pdf.
  • Skrzypczak-Jankun, E., Borbulevych, O. Y., Jankun, J. Soybean lipoxygenase-3 in complex with 4-nitrocatechol. Acta Crystallogr D Biol Crystallogr, 60:Pt3, 613-615, 2004, full text in pdf.
  • Borbulevych, O. Y., Jankun, J., Selman, S. H., Skrzypczak-Jankun, E. Lipoxygenase interactions with natural flavonoid, quercetin, reveal a complex with protocatechuic acid in its X-ray structure at 2.1 A resolution, Proteins, 54:1, 13-19, 2004, full paper in pdf.
  • Wojtowicz, A., Selman, S., Jankun, J. Computer simulation of prostate cryoablation--fast and accurate approximation of the exact solution. Computer Aided Surgery, 8:2, 91-97, 2003, full paper in pdf .
  • Chorostowska-Wynimko, J., Skrzypczak-Jankun, E., Jankun, J. Plasminogen activator inhibitor type-1: its structure, biological activity and role in tumorigenesis (Review), International Journal of Molecular Medicine, 13:6, 759-766, 2004, full paper in pdf.
  • Chorostowska-Wynimko, J., Swiercz, R., Skrzypczak-Jankun, E., Wojtowicz, A., Selman, S. H., Jankun, J. A novel form of the plasminogen activator inhibitor created by cysteine mutations extends its half-life: relevance to cancer and angiogenesis, Molecular Cancer Therapeutics, 2:1, 19-28, 2003, full paper in pdf, journal cover.
  • Skrzypczak-Jankun, E., Zhou, K., Jankun, J. Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead. International Journal of Molecular Medicine, 12:4, 415-420, 2003, full paper in pdf.
  • Aniola, J., Selman, S. H., Lilge, L., Keck, R., Jankun, J. Spatial distribution of liposome encapsulated tin etiopurpurin dichloride (SnET2) in the canine prostate: implications for computer simulation of photodynamic therapy. International Journal of Molecular Medicine, 11:3, 287-291, 2003, full paper in pdf.
  • Jankun, J, Skrzypczak-Jankun, E. Binding site of amiloride to urokinase plasminogen activator depends on species. International Journal of Molecular Medicine, 8:4, 365-371, 2001, full paper in pdf.
  • Swiercz, R., Keck, R. W., Skrzypczak-Jankun, E., S, Selman, H. S., and Jankun, J. Recombinant PAI-1 inhibits angiogenesis and reduces size of LNCaP prostate cancer xenografts in SCID mice, Oncology Reports, 8: 463-470, 2001, full paper in pdf.
  • Zaim, A., Keck, R. W., Selman, S. H., Jankun, J. Two-dimensional Ultrasound Image Matching System for Photodynamic Therapy, Proceedings of BIOS-SPIE, 4244: 327-337, 2001.
  • Skrzypczak-Jankun, E., McCabe, P. N., Selman, S. H., and Jankun, J. Curcumin Inhibits Lipoxygenase by Binding to its Central Cavity: Theoretical and X-ray Evidence. International Journal of Molecular Medicine, 6: 521-526, 2000, full paper in pdf.
  • McCabe, N.P, Angwafo, F. III, Zaher, A., Selman SH, Kouanche A, and Jankun J. Expression of Soluble Urokinase Plasminogen Activator Receptor May be Related to Outcome in Prostate Cancer Patients, Oncology Reports, 7: 879-882, 2000, full paper in pdf.
  • Jankun, J., Zaim, A., Jankun-Kelly, M., Keck, R. W. and Selman, S. H. Computer Model for Photodynamic Therapy of the Prostate. Proceedings of SPIE, 3907: 222-228, 2000.
  • Jankun, M., T.J. Kelly, Zaim, A. Young, K., Keck, R. W., Selman, S. H., and J Jankun. Computer Model for Cryosurgery of the Prostate, Computer Aided Surgery, 4: 193-199, 1999, full paper in pdf.
  • Swiercz R, Skrzypczak-Jankun E, Merrell M M, Selman H S, Jankun J. Angiostatic Activity of Synthetic Inhibitors of Urokinase Type Plasminogen Activator, Oncology Reports, 6: 523-536, 1999 full paper in pdf.
  • Jankun J, Skrzypczak-Jankun, E. Molecular Basis of Specific Inhibition of Urokinase Plasminogen Activator by Amiloride, Cancer Biochemistry Biophysics, 17:109-123, 1999, full paper in pdf
  • Swiercz R. Wolfe JD, Zaher A. Jankun J. Expression of the plasminogen activation system in kidney cancer correlates with its aggressive phenotype, Clinical Cancer Research, 4(4), 869-877, 1998, full text in pdf.
  • Chau Pham, Jankun, J. Skrzypczak-Jankun, E. Flowers II, R.A.and Funk, M. O. Jr. Structural and Thermochemical Characterization of Lipoxygenase Catechol Complexes. Biochemistry, 37(51): 17952-17957, 1998, full text in pdf.
  • Jankun J. Keck RW, Skrzypczak-Jankun E, Swiercz, R. Inhibitors of urokinase reduce size of prostate cancer xenografts in severe combined immunodeficient mice, Cancer Research, 57(4), 559-563, 1997, full text in pdf..
  • Jankun J, Selman SH, Swiercz R, Skrzypczak-Jankun E. Why drinking green tea could prevent cancer, Nature, 387, 6633, 562, 1997, full paper in pdf.
  • Jankun J. Antitumor activity of the type 1 plasminogen activator inhibitor and cytotoxic conjugate in vitro, Cancer Research, 52(20), 5829-5832, 1992, full text in pdf.
  • Jankun, J., Maher, V. M., and McCormick, J. J. Malignant transformation of human fibroblasts correlates with increased activity of receptor-bound plasminogen activator. Cancer Research, 51: 1221-1226, 1991, full paper in pdf.
  • Jankun J, Matsumura F, Kaneko H, Trosko JE, Pellicer A, Greenberg AH. Plasmid-aided insertion of MMTV-LTR and ras DNAs to NIH 3T3 fibroblast cells makes them responsive to 2,3,7,8-TCDD causing overexpression of p21ras and down-regulation of EGF receptor, Mol Toxicol, 2(3), 177-186, 1989.
  • Bombick DW, Jankun, J, Tullis K, Matsumura F. 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes increases in expression of c-erb-A and levels of protein-tyrosine kinases in selected tissues of responsive mouse strains, Proc Natl Acad Sci U S A, 85(12), 4128-4132, 1988, full paper in pdf.